The organic synthesis research conducted at COBRA has application to fields as varied as pharmaceuticals, cosmetics and food processing, as well as environmental, energy and material related studies. These activities are in close collaboration with the analysis and separation methods departments of the Engineering & Innovation Center.
The department is organised into five main research axes:
The researchers have modern equipment at their disposal for analysis methods (NMR, chromatography, mass & RX) and the latest synthesis techniques (hyperbaric reactions, synthesis machines etc).
Through the support of the Haute Normandy Region, which has the theme ‘Biologie, Chimie, Santé’ (Chemistry, Biology, Health) as one of its main priorities in research, the laboratories can count on numerous regional pharmaceutical centers for the development of international recognition. Strong partnerships have been developed with large groups, both French and foreign, of the pharmaceutical, cosmetic, food processing and petrochemical industries.
Examples of services provided:
· Advice & expertise in organic synthesis
· Development of reactions or pathways to complex molecules.
· Areas of expertise: heterocycles, polyenics, organofluorines, cyclodextrins.
· Syntheses catalyzed by metals or organocatalysts for sustainable chemistry.
· Reactions under hyperbaric conditions- electrosynthesis – activation by microwaves.
· Production of fluorescent biomarkers and radiotracers.
· Study of reactions by IR in-situ analysis.
· ‘Made-to-measure’ training in numerous fields of synthesis.
Jean-François Brière, CNRS
Tel : 02.35.52.24.64
Laurent Bischoff, Professor
Tel : 02.35.52.29.03
The COBRA laboratory is a mixed research unit (UMR-6014) combining the CNRS, INSA Rouen and the University of Rouen. It is located at the IRCOF (Institute of Fine Organic Chemistry Research) at the University of Rouen, in Mont Saint Aignan. One of the major assets of the laboratory is the fact that it develops its research activities in both Organic Synthesis and Analytical Chemistry. It has exceptional technical support facilities (C2I Orga) with state of the art equipment for the latest innovative methods. COBRA has recognized expertise in heterocyclic, organometallic, fluorine, bioorganic and analytical chemistry. The research touches the domains of pharmaceuticals, medical imaging, cosmetics, food processing, the environment and energy. Our Missions : Discover new concepts, innovative methodologies of synthesis and new structures, analyze structures and mechanisms, develop the interaction between chemistry and biosciences, contribute to the transfer of expertise to industry, train quality professionals through research.